In this study, researchers tested whether lithium ascorbate, a potentially gentler alternative to traditional lithium medications, could trigger allergic reactions — both immediate and delayed — in guinea pigs and mice.

How The Experiment Was Done

Animals received injections of lithium ascorbate. Guinea pigs were used to test for immediate allergic reactions within 20 minutes after exposure. Mice were used to test for delayed immune responses that appear 24-48 hours after exposure. Scientists observed animals for up to two weeks to determine allergic symptoms, behavioral changes, and clinical signs.

Key Findings

Across all tested doses — including amounts up to 10 times the highest expected therapeutic dose — no signs of allergic reaction were found.

• The animals showed no skin irritation or swelling.

• No delayed-type hypersensitivity reactions were seen in mice even after high-dose exposure.

• There were no deaths, behavioral changes, or signs of distress.

• No clinical abnormalities were recorded in body weight and appearance.

What Does It Mean For You?

If you're sensitive or prone to allergies, traditional lithium salts may carry risks of immune reactions. In contrast, this study shows that lithium ascorbate did not trigger allergic responses in animals, even at high doses. Lithium ascorbate may be a safer and more tolerable alternative for long-term use.

Interested in learning more about this study? Take a look at the full text.