Normotim (lithium ascorbate) outperformed lithium orotate in an animal study without causing significant weight gain. The difference is worth a closer look.

Normotim: Less Anxiety, Less Stress

Rats treated with Normotim were more active and more relaxed during the stress experiments.

Compared to the control group, rats on Normotim showed 35% improvement while animals on the same elemental lithium dose of lithium orotate only showed 14.5%.

Researchers say that it is likely Normotim has high bioavailability at low doses.

Do you care about your weight? Watch out for lithium orotate

Rats receiving lithium orotate gained about 16% of their body weight, while rats receiving Normotim (lithium ascorbate) gained only 3%.

Differences in weight gain on Normotim (lithium ascorbate) and lithium orotate

To put 16% into perspective, for a 160-pound person, that would be about 26 pounds of weight gain.

Weight gain for lithium orotate according to study model

For lithium ascorbate, the weight change didn't differ much from the control group.

Weight gain for lithium ascorbate according to study model

In Short

Animals taking Normotim were:

• Less stressed
• More active
• Gained little to no weight

Author

Vlada Sukhanovskaya

Read Next

• Depressed and Obese People May Benefit from Lithium
• Losing Weight With The Support Of Lithium Ascorbate
• Can Food Give You Enough Lithium?

Scientific Sources

• Ostrenko, K., & Rastashansky, V. Study of the Antidepressant and Anxiolytic Effects of Various Lithium Salts. https://cdn.shopify.com/s/files/1/0632/4568/0810/files/Study_of_the_Antidepressant_and_Anxiolytic_Effects_of_Various_Lithium_Salts.pdf?v=1782295342
• Deltsov, A. A., & Pozyabin, S. V. Comparative Analysis of the Stress-Protective Effects of Lithium Salts in the Open Field Test. Methods and Technologies in Biomedical Studies. UDC 612.57 https://cdn.shopify.com/s/files/1/0632/4568/0810/files/Open_field_test.pdf?v=1775470107
• K.S. Ostrenko, A.A. Deltsov, S.V. Pozyabin et al. Convergent Antidepressant-Like and Stress-Attenuating Effects of Lithium Ascorbate in Rodent Behavioral and Physiological Models, 03 August 2026, PREPRINT (Version 1) Research Square https://doi.org/10.21203/rs.3.rs-10524904/v1